UGT1A8

UDP glucuronosyltransferase 1 family, polypeptide A8
Identifiers
Symbols	UGT1A8 ; UDPGT; UDPGT 1-8; UGT-1H; UGT1-08; UGT1.8; UGT1A8S; UGT1H
External IDs	OMIM: 606433 MGI: 3576090 HomoloGene: 133281 ChEMBL: 1743318 GeneCards: UGT1A8 Gene
EC number	2.4.1.17
Gene ontology Molecular function • retinoic acid binding • enzyme inhibitor activity • steroid binding • fatty acid binding • drug binding • glucuronosyltransferase activity • enzyme binding • protein homodimerization activity • protein heterodimerization activity Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • integral component of membrane Biological process • fatty acid metabolic process • steroid metabolic process • coumarin metabolic process • flavonoid biosynthetic process • drug metabolic process • cellular response to hormone stimulus • retinoic acid metabolic process • negative regulation of catalytic activity • negative regulation of fatty acid metabolic process • negative regulation of steroid metabolic process • flavone metabolic process • cellular glucuronidation • flavonoid glucuronidation • xenobiotic glucuronidation • negative regulation of glucuronosyltransferase activity • negative regulation of cellular glucuronidation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54576	394430
Ensembl	ENSG00000242366	ENSMUSG00000090165
UniProt	Q9HAW9	D3Z7G0
RefSeq (mRNA)	NM_019076	NM_201641
RefSeq (protein)	NP_061949	NP_964003
Location (UCSC)	Chr 2: 233.62 – 233.77 Mb	Chr 1: 88.06 – 88.22 Mb
PubMed search	[1]	[2]

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.