MAS1 oncogene
From Infogalactic: the planetary knowledge core
| MAS1 oncogene | |
|---|---|
| Identifiers | |
| Symbol | MAS1 |
| Entrez | 4142 |
| HUGO | 6899 |
| OMIM | 165180 |
| RefSeq | NM_002377 |
| UniProt | P04201 |
| Other data | |
| Locus | Chr. 6 q24-q27 |
| MAS1 oncogene-like | |
|---|---|
| Identifiers | |
| Symbol | MAS1L |
| Entrez | 116511 |
| HUGO | 13961 |
| OMIM | 607235 |
| RefSeq | NM_052967 |
| UniProt | P35410 |
| Other data | |
| Locus | Chr. 6 p21 |
The MAS1 oncogene is a G protein-coupled receptor[1] which binds the angiotensin-II metabolite angiotensin-(1-7).[2][3] The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor. Hence MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure.[4]
References
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<references />, or <references group="..." />External links
- IUPHAR GPCR Database - MAS1
- IUPHAR GPCR Database - MAS1L
- proto-oncogene proteins c-mas-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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