Cysteinyl leukotriene receptor 1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Cysteinyl leukotriene receptor 1 is a protein that in humans is encoded by the CYSLTR1 gene.[1][2][3]
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system.[4] Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.[3]
See also
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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