MT-45

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
MT-45
MT-45 svg.svg
Systematic (IUPAC) name
1-Cyclohexyl-4-(1,2-diphenylethyl)piperazine
Clinical data
Legal status
Routes of
administration		 oral administration
Identifiers
CAS Number 52694-55-0 N 52694-52-7 (S) enantiomer
ATC code none
PubChem CID: 431865
ChemSpider 381935 N
Synonyms MT-45, IC-6
Chemical data
Formula C24H32N2
Molecular mass 348.523 g/mol
  • c3ccccc3CC(c2ccccc2)N(CC1)CCN1C4CCCCC4
  • InChI=1S/C24H32N2/c1-4-10-21(11-5-1)20-24(22-12-6-2-7-13-22)26-18-16-25(17-19-26)23-14-8-3-9-15-23/h1-2,4-7,10-13,23-24H,3,8-9,14-20H2 N
  • Key:IGBRRSIHEGCUEN-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co.[1] It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine).[2][3] It has been used as a lead compound from which a large family of potent opioid drugs[4] have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes.[5][6][7][8][9][10]

Recreational use of MT-45 has been associated with hearing loss and unconsciousness.[11]

MT-45 became a class A drug in the UK on 11 March 2015[12]

MT-45 is banned in the Czech Republic.[13]

See also

References

<templatestyles src="Reflist/styles.css" />

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />
  1. ↑ US patent 3957788, Haruki Nishimura, Hitoshi Uno, Kagayaki Natsuka, Noriaki Shimokawa, Masanao Shimizu, Hideo Nakamura, "1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts", published 1975-15-01, issued 1976-18-05 
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ US Patent 4080453
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  12. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  13. ↑ Lua error in package.lua at line 80: module 'strict' not found.
Retrieved from "https://infogalactic.com/w/index.php?title=MT-45&oldid=713218756"