Tanezumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | NGF |
| Identifiers | |
| CAS Number | 880266-57-9  |
| ATC code | none |
| UNII | EQL0E9GCX1  |
| Synonyms | RN624 |
| Chemical data | |
| Formula | C6464H9942N1706O2026S46 |
| Molecular mass | 145.4 kg/mol |
| (what is this?) (verify) |
|
Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor. It was developed by Pfizer as a treatment for pain.[1]
In 2009 there was a Phase III trial for knee pain due to osteoarthritis (OA).[2] Another phase III trial for hip pain in OA [3] was halted in June 2010 when some patients needed hip replacement.[4]
Tanezumab is undergoing Phase II clinical trials for the treatment of various pain entities, including chronic low back pain, bone cancer pain, and interstitial cystitis.[5]
In march of 2012 the Anti-NGF Testing - FDA Committee voted in favor of a continuation of the development of nerve-blocking medications, as long as certain safety precautions were observed.
A phase III trial published in 2013 found tanezumab was superior to placebo for painful hip osteoarthritis.[6]
References
- ↑ N05, American Medical Association.
- ↑ Lua error in package.lua at line 80: module 'strict' not found. 2009
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://www.genengnews.com/gen-news-highlights/trials-halted-as-pfizer-s-tanezumab-shown-to-worsen-osteoarthritis/81243572/
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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