Propacetamol

Propacetamol

Systematic (IUPAC) name
4-(acetamido)phenyl N,N-diethylglycinate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	IV
Pharmacokinetic data
Biological half-life	2.4 hours
Excretion	Renal
Identifiers
CAS Number	66532-85-2
ATC code	N02BE05 (WHO)
PubChem	CID: 68865
ChemSpider	62097
UNII	5CHW4JMR82 Y
Chemical data
Formula	C14H20N2O3
Molecular mass	264.3202 g/mol
SMILES CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
InChI InChI=1S/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17) Key:QTGAJCQTLIRCFL-UHFFFAOYSA-N
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Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V. It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol given orally. 2 g of propacetamol are equivalent to 1g of paracetamol.

See also

• Paracetamol