Salsalate
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| Systematic (IUPAC) name | |
|---|---|
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2-(2-Hydroxybenzoyl)oxybenzoic acid
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| Clinical data | |
| Trade names | Disalcid, Salflex |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682880 |
| Pregnancy category |
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| Legal status |
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| Identifiers | |
| CAS Number | 552-94-3  |
| ATC code | N02BA06 (WHO) |
| PubChem | CID: 5161 |
| DrugBank | DB01399 |
| ChemSpider | 4977  |
| UNII | V9MO595C9I |
| KEGG | D00428 |
| ChEBI | CHEBI:9014 |
| Chemical data | |
| Formula | C14H10O5 |
| Molecular mass | 258.23 g/mol |
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Salsalate is a medication that belongs to the salicylate and non-steroidal anti-inflammatory drug (NSAID) classes. Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several proinflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein.[1] The mechanism through which salsalate is thought to reduce the production of these inflammatory chemical signals is through the inhibition of IκB kinase resulting in decreased action of NF-κB genes.[1][2][3] This mechanism is thought to be responsible for salsalate's insulin-sensitizing and blood sugar lowering properties.[2] Salsalate is the generic name of a prescription drug marketed under the brandnames Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand name formulations may be available.[4]
Medical uses
Salsalate may be used for inflammatory disorders such as rheumatoid arthritis or noninflammatory disorders such as osteoarthritis.[1][5]
Safety
The risk of bleeding is a common concern with use of the NSAID class of medications. However, the bleeding risk associated with salsalate is lower than that associated with aspirin use.[2]
Research
Salsalate has been proposed for the prevention and treatment of type 2 diabetes mellitus due to its ability to lower insulin resistance associated with inflammation and may be useful in prediabetes.[1] However, the use of salsalate to prevent the progression from prediabetes to type 2 diabetes mellitus has received limited study.[1]
History
Salsalate had been suggested as possible treatment for diabetes as early as 1876.[1][6][7]
Synthesis
References
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- ↑ drugs.com Salsalate entry
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