5F-AMB
Systematic (IUPAC) name | |
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(S)-methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate
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Clinical data | |
Legal status |
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Identifiers | |
CAS Number | 1715016-74-2 |
Chemical data | |
Formula | C19H26FN3O3 |
Molecular mass | 363.43 g·mol−1 |
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5F-AMB (also known as 5F-MMB-PINACA and 5F-AMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family,[1] which has been used as an active ingredient in synthetic cannabis products. It was first identified in Japan in early 2014.[2][3] Although only very little pharmacological information about 5F-AMB itself exists,[4] its 4-cyanobutyl analogue (instead of 5-fluoropentyl) has been reported to be a potent agonist for the CB1 receptor (Ki = 0.7 nM).[5]
Contents
Side effects
5F-AMB intoxication caused one fatality on its own[6] and another one through ketoacidosis in combination with AB-CHMINACA, AB-FUBINACA, AM-2201, 5F-APINACA, EAM-2201, JWH-018, JWH-122, MAM-2201, STS-135 and THJ-2201 and another fatality in combination with AB-CHMINACA and Diphenidine.[7][8]
Legality
5F-AMB is an Anlage II controlled substance in Germany as of May 2015.[9]
Sweden's public health agency suggested classifying 5F-AMB as hazardous substance on November 10, 2014.[10]
The state of Louisiana banned 5F-AMB through an emergency rule after it was detected in a synthetic cannabis product called "Kali Berry 2" on 3 June 2014.[11]
5F-AMB is controlled by the Fifth Schedule of the Misuse of Drugs Act (MDA) in Singapore as of May 2015.[12]
5F-AMB was also scheduled in Japan on July 25, 2014.[13]
As of October 2015 5F-AMB is a controlled substance in China.[14]
See also
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References
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- ↑ Buchler IP et al., INDAZOLE DERIVATIVES. WO 2009/106980
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- ↑ http://npsdb.nihs.go.jp/Search/Default_e.aspx
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- Indazoles
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