SR-144,528

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SR-144,528
SR-144528 structure.png
Systematic (IUPAC) name
N-[(1S)-endo-1,3,3-trimethylbicyclo [2.2.1]heptan2-yl]-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxamide
Identifiers
CAS Number 192703-06-3 YesY
ATC code none
PubChem CID: 3081355
IUPHAR/BPS 751
ChEMBL CHEMBL381689 N
Chemical data
Formula C29H34ClN3O
Molecular mass 476.051 g/mol
  • Cc5ccc(cc5)Cn3nc(cc3-c(cc2C)ccc2Cl)C(=O)NC1C(C)(C)C(C4)CCC14C
 NYesY (what is this?)  (verify)

SR144528 is a drug that acts as a potent and highly selective CB2 receptor inverse agonist, with a Ki of 0.6nM at CB2 and 400nM at the related CB1 receptor.[1][2] It is used in scientific research for investigating the function of the CB2 receptor,[3][4][5] as well as for studying the effects of CB1 receptors in isolation, as few CB1 agonists that do not also show significant activity as CB2 agonists are available.[6][7][8] It has also been found to be an inhibitor of acyl-coenzymeA:cholesterol acyltransferase, an effect that appears to be independent from its action on CB2 receptors.[9]

See also

References

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