O-1602

O-1602

Systematic (IUPAC) name
5-methyl-4-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene-1,3-diol
Identifiers
CAS Number	317321-41-8
PubChem	CID: 45073499
IUPHAR/BPS	5525
ChemSpider	23014383
Chemical data
Formula	C17H22O2
Molecular mass	258.16
SMILES CC1=C[C@@H](C2=C(C)C=C(O)C=C2O)[C@H](C(C)=C)CC1
InChI InChI=1S/C17H22O2/c1-10(2)14-6-5-11(3)7-15(14)17-12(4)8-13(18)9-16(17)19/h7-9,14-15,18-19H,1,5-6H2,2-4H3/t14-,15+/m0/s1 Key:KDZOUSULXZNDJH-LSDHHAIUSA-N

O-1602 is a synthetic compound most closely related to abnormal cannabidiol, and more distantly related in structure to cannabinoid drugs such as THC. O-1602 does not bind to the classical cannabinoid receptors CB₁ or CB₂ with any significant affinity, but instead is an agonist at several other receptors which appear to be related to the cannabinoid receptors, particularly GPR18 and GPR55. These previously orphan receptors have been found to be targets for a number of endogenous and synthetic cannabinoid compounds, and are thought to be responsible for most of the non-CB₁, non-CB₂ mediated effects that have become evident in the course of cannabinoid research. O-1602 produces some effects shared with classical cannabinoid compounds such as analgesic and antiinflammatory effects and appetite stimulation, but it does not produce sedation or psychoactive effects, and has several actions in the gut and brain that are not shared with typical cannabinoid agonists.

See also

• Cannabidiol
• O-1918