JWH-149

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JWH-149
File:JWH-149.png
Systematic (IUPAC) name
(4-methyl-1-naphthalenyl)(2-methyl-1-pentyl-1H-indol-3-yl)methanone
Clinical data
Legal status
Identifiers
CAS Number 548461-82-1 YesY
PubChem CID: 45267820
ChemSpider 24627235
UNII AWD731Y25Z YesY
Chemical data
Formula C26H27NO
Molecular mass 369.50 g/mol
  • c4cccc1c4c(ccc1C)C(=O)c3c2ccccc2n(c3C)CCCCC
  • InChI=1S/C26H27NO/c1-4-5-10-17-27-19(3)25(23-13-8-9-14-24(23)27)26(28)22-16-15-18(2)20-11-6-7-12-21(20)22/h6-9,11-16H,4-5,10,17H2,1-3H3
  • Key:JTJAMXUOXJGSCW-UHFFFAOYSA-N

JWH-149 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-pentyl analog of JWH-148. It is a potent but only moderately selective ligand for the CB2 receptor, with a binding affinity of Ki = 0.73 ± 0.03 nM at this subtype, and more than 6 times selectivity over the CB1 subtype.[1]

See also

References

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