Brallobarbital

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Brallobarbital
Brallobarbital.svg
Brallobarbital ball-and-stick animation.gif
Systematic (IUPAC) name
5-(2-Bromoprop-2-en-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
Identifiers
CAS Number 561-86-4 YesY
ATC code none
PubChem CID: 68416
ChemSpider 61699 YesY
UNII D0N7A2M3MU YesY
ChEMBL CHEMBL2106093 N
Synonyms Brallobarbital
Chemical data
Formula C10H11BrN2O3
Molecular mass 287.110 g/mol
  • O=C1NC(=O)NC(=O)C1(CC(\Br)=C)C\C=C
  • InChI=1S/C10H11BrN2O3/c1-3-4-10(5-6(2)11)7(14)12-9(16)13-8(10)15/h3H,1-2,4-5H2,(H2,12,13,14,15,16) YesY
  • Key:DYODAJAEQDVYFX-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Brallobarbital is a barbiturate developed in the 1920s.[1] It has sedative and hypnotic properties, and was used for the treatment of insomnia. Brallobarbital was primarily sold as part of a combination product called Vesparax, composed of 150 mg secobarbital, 50 mg brallobarbital and 50 mg hydroxyzine.[2] The long half-life of this combination of drugs tended to cause a hangover effect the next day,[3] and Vesparax fell into disuse once newer drugs with lesser side effects had been developed.[4]

References

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  1. ↑ US Patent 1869666
  2. ↑ Lhermann J. Clinical application of a new very active hypnotic associating sodium secobarbital, calcium brallobarbital and hydroxyzine (UC-8130). Gazette Medicale de France. 1964 Mar 10;71:961-2. (French)
  3. ↑ Yih TD, Rossum JM. Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication. Xenobiotica. 1976 Jun;6(6):355-62.
  4. ↑ Fischbach R. Efficacy and safety of midazolam and vesparax in treatment of sleep disorders. British Journal of Clinical Pharmacology. 1983;16 Suppl 1:167S-171S.
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