ELB-139

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ELB-139
ELB-139.png
Systematic (IUPAC) name
1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-one
Identifiers
CAS Number 188116-08-7 YesY
PubChem CID: 11277418
ChemSpider 9452418
Chemical data
Formula C14H16ClN3O
Molecular mass 277.749 g/mol
  • Clc3ccc(cc3)N1CC(=NC1=O)N2CCCCC2
  • InChI=1S/C14H16ClN3O/c15-11-4-6-12(7-5-11)18-10-13(16-14(18)19)17-8-2-1-3-9-17/h4-7H,1-3,8-10H2
  • Key:YGXIELIREXEJQN-UHFFFAOYSA-N
  (verify)

ELB-139 (LS-191,811) is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1][2]

ELB-139 is a subtype-selective partial agonist at GABAA receptors, with highest affinity for the α3 subtype, but highest efficacy at α1 and α2.[3] It has primarily anxiolytic and anticonvulsant effects, but produces little sedative effects or ataxia,[4] and has also been demonstrated in rats to increase serotonin levels in the striatum and prefrontal cortex, without affecting dopamine levels.[5] It has been proposed as a possible candidate for a novel non-sedating anxiolytic or anticonvulsant drug for use in humans[6] The sponsor elbion AG registered a clinical trial in ClinicalTrials.gov for the treatment of anxiety associated with panic disorder but the results have not been reported.[7] It was developed by Arzeitmittelwerk Dresden in the 1990s.[8]

References

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  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ US Patent 5869481 Anticonvulsive 1-ar(alk)ylimidazolin-2-ones and process for making


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