Sulazepam

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Sulazepam
200px
Systematic (IUPAC) name
7-Chloro-1-methyl-5-phenyl-1,3-dihydro- 2H-1,4-benzodiazepine-2-thione
Clinical data
Legal status
Identifiers
CAS Number 2898-13-7 YesY
ATC code none
PubChem CID: 17931
ChemSpider 16935 YesY
UNII NZ779Q5S0W YesY
KEGG D05942 YesY
Chemical data
Formula C16H13ClN2S
Molecular mass 300.81 g/mol
  • ClC1=CC=C(N(C)C(CN=C2C3=CC=CC=C3)=S)C2=C1
  • InChI=1S/C16H13ClN2S/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 YesY
  • Key:MWGWTOPCKLQYEU-UHFFFAOYSA-N YesY
  (verify)

Sulazepam is a benzodiazepine derivative. It is the thioamide derivative of diazepam. It is metabolised into diazepam, desmethyldiazepam and oxydiazepam. It has sedative, muscle relaxant, hypnotic, anticonvulsant and anxiolytic properties like those of other benzodiazepines.[1][2] It was never marketed.

Synthesis

File:Sulazepam synthesis.svg
Sulazepam synthesis:[3] U.S. Patent 3,141,890

Treatment of diazepam with phosphorus pentasulfide produces the corresponding thionamide, sulazepam.

See also

References

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