Iclazepam

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Iclazepam
Iclazepam.svg
Systematic (IUPAC) name
7-chloro-1-[2-(cyclopropylmethoxy)ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one
Identifiers
CAS Number 57916-70-8 YesY
PubChem CID: 68777
ChemSpider 62020 YesY
UNII FL061Q6NMC YesY
ChEMBL CHEMBL2104257
Chemical data
Formula C21H21ClN2O2
Molecular mass 368.857 g/mol
  • ClC1=CC2=C(C=C1)N(CCOCC3CC3)C(CN=C2C4=CC=CC=C4)=O
  • InChI=1S/C21H21ClN2O2/c22-17-8-9-19-18(12-17)21(16-4-2-1-3-5-16)23-13-20(25)24(19)10-11-26-14-15-6-7-15/h1-5,8-9,12,15H,6-7,10-11,13-14H2 YesY
  • Key:PLRHQQPBNXIHAZ-UHFFFAOYSA-N YesY
  (verify)

Iclazepam (Clazepam) is a drug which is a benzodiazepine derivative. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and is around the same potency as chlordiazepoxide.

Iclazepam is a derivative of nordazepam substituted with a cyclopropylmethoxyethyl group on the N1 nitrogen. Once in the body, iclazepam is quickly metabolised to nordazepam and its N-(2-hydroxyethyl) derivative, which are thought to be mainly responsible for its effects.[1]

See also

References

  1. ↑ Giudicelli JF, Berdeaux A, Idrissi N, Richer C. Clazepam: pharmacokinetics and effects on performance. British Journal of Clinical Pharmacology. 1978 Jan;5(1):65-9.

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