EIF2AK3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Eukaryotic translation initiation factor 2-alpha kinase 3, also known as PKR-like endoplasmic reticulum kinase or protein kinase R (PKR)-like endoplasmic reticulum kinase, is an enzyme that in humans is encoded by the EIF2AK3 gene.[1][2][3][4]
Contents
Function
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins.[2]
Clinical significance
Patients with mutations in this gene develop Wolcott-Rallison syndrome.[5]
Interactions
EIF2AK3 has been shown to interact with DNAJC3[6] and NFE2L2.[7]
Inhibitors
- GSK2606414
- 3-Fluoro-GSK2606414
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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