PRKCD

See also: Protein kinase C

Protein kinase C, delta
250px PDB rendering based on 1bdy.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1YRK, 2YUU
Identifiers
Symbols	PRKCD ; ALPS3; CVID9; MAY1; PKCD; nPKC-delta
External IDs	OMIM: 176977 MGI: 97598 HomoloGene: 55963 ChEMBL: 2996 GeneCards: PRKCD Gene
EC number	2.7.10.2, 2.7.11.13
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • protein kinase C activity • calcium-independent protein kinase C activity • non-membrane spanning protein tyrosine kinase activity • protein binding • ATP binding • enzyme activator activity • enzyme binding • insulin receptor substrate binding • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm • mitochondrion • endoplasmic reticulum • cytosol • plasma membrane • cell-cell junction • nuclear matrix • perinuclear region of cytoplasm • extracellular exosome Biological process • stimulatory C-type lectin receptor signaling pathway • protein phosphorylation • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • cell cycle • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • blood coagulation • fibroblast growth factor receptor signaling pathway • intrinsic apoptotic signaling pathway in response to oxidative stress • gene expression • regulation of receptor activity • programmed cell death • immunoglobulin mediated immune response • peptidyl-threonine phosphorylation • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • termination of signal transduction • platelet activation • negative regulation of actin filament polymerization • negative regulation of protein binding • interleukin-10 production • interleukin-12 production • positive regulation of superoxide anion generation • regulation of actin cytoskeleton organization • negative regulation of glial cell apoptotic process • positive regulation of protein dephosphorylation • Fc-gamma receptor signaling pathway involved in phagocytosis • B cell proliferation • neutrophil activation • defense response to bacterium • negative regulation of MAP kinase activity • innate immune response • negative regulation of insulin receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • negative regulation of inflammatory response • negative regulation of peptidyl-tyrosine phosphorylation • protein stabilization • negative regulation of filopodium assembly • cell chemotaxis • interferon-gamma-mediated signaling pathway • negative regulation of platelet aggregation • cellular senescence • positive regulation of phospholipid scramblase activity • positive regulation of ceramide biosynthetic process • positive regulation of glucosylceramide catabolic process • positive regulation of sphingomyelin catabolic process • positive regulation of response to DNA damage stimulus • positive regulation of apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PRKCD 202545 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5580	18753
Ensembl	ENSG00000163932	ENSMUSG00000021948
UniProt	Q05655	P28867
RefSeq (mRNA)	NM_006254	NM_011103
RefSeq (protein)	NP_006245	NP_035233
Location (UCSC)	Chr 3: 53.16 – 53.19 Mb	Chr 14: 30.6 – 30.63 Mb
PubMed search	[1]	[2]

Protein kinase C delta type is an enzyme that in humans is encoded by the PRKCD gene.

Function

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Protein kinase C delta is also regulated by phosphorylation on various serine/threonine (e.g. T50, T141, S304, T451, T505, S506, T507, S643, S664) and tyrosine residues including Y311 (by SRC).

Interactions

PRKCD has been shown to interact with:

• C1QBP,
• INSR,
• MUC1,
• MTOR,
• PLD2,
• PTPN6,
• PTPRM,
• PDPK1,
• RASGRP3,
• SHC1 and
• STAT1.