PRKCI

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.

Function

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Interactions

PRKCI has been shown to interact with:

• Centaurin, alpha 1,
• FRS2,
• Glyceraldehyde 3-phosphate dehydrogenase,
• PARD3,
• Phosphoinositide-dependent kinase-1,
• SMG1 (gene), and
• Sequestosome 1.