Aceclofenac

Aceclofenac

Systematic (IUPAC) name
2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid
Clinical data
Trade names	Hifenac, Cincofen, Nacsiv, Acenac
AHFS/Drugs.com	International Drug Names
Legal status	UK: POM (Prescription only)
Routes of administration	oral, topical
Identifiers
CAS Number	89796-99-6 N
ATC code	M01AB16 (WHO) M02AA25
PubChem	CID: 71771
ChemSpider	64809 Y
UNII	RPK779R03H Y
KEGG	D01545 Y
ChEBI	CHEBI:31159 N
ChEMBL	CHEMBL93645 Y
Chemical data
Formula	C16H13Cl2NO4
Molecular mass	354.18472 g/mol
SMILES Clc2cccc(Cl)c2Nc1ccccc1CC(=O)OCC(=O)O
InChI InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21) Y Key:MNIPYSSQXLZQLJ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The dose is 100 mg twice daily.

It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.

It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac.

Synthesis

Aceclofenac synthesis.

References

• British National Formulary 55, March 2008; ISBN 978-0-85369-776-3 p. 537