Dazoxiben

Dazoxiben

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Identifiers
CAS Number	78218-09-4 N
ChEMBL	ChEMBL267473 Y
ChemSpider	47885 Y
DrugBank	DB03052 Y
IUPHAR/BPS	5175
Jmol 3D model	Interactive image
PubChem	53001
UNII	09ZFC7974Q Y
InChI InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16) Y Key: XQGZSYKGWHUSDH-UHFFFAOYSA-N Y InChI=1/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16) Key: XQGZSYKGWHUSDH-UHFFFAOYAY
SMILES O=C(O)c2ccc(OCCn1ccnc1)cc2
Properties
Chemical formula	C12H12N2O3
Molar mass	232.24 g·mol−1
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Dazoxiben is an orally active thromboxane synthase inhibitor. It has shown a significant clinical improvement in patients with Raynaud's syndrome.

Synthesis

File:Dazoxiben synthesis.svg

Dazoxiben synthesis:

One convenient synthesis starts with the O-chloroethyl ether of p-hydroxybenzamide and proceeds bydisplacement with imidazole to give 2. Hydrolysis of the amide function completes the synthesis of dazoxiben.