Prostaglandin DP1 receptor

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Prostaglandin D2 receptor 1 (DP1) is a G protein-coupled receptor, encoded by the PTGDR1 gene, for prostaglandin D2 (PGD2).[1]


Mechanism

DP1 is a G protein-coupled receptor (GPCR). Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.

Function

Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2, functions as a mast cell-derived mediator to trigger asthmatic responses.[1] It also causes vasodilation

Ligands

Agonists
Antagonists [2]

See also

References

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External links

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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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