CD11a
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.
Function
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.[1]
CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.
Efalizumab acted as an immunosuppressant by binding to CD11a, but was withdrawn in 2009 due to severe side effects being associated with the drug.
Interactions
CD11a has been shown to interact with ICAM-1.[2][3][4]
See also
References
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External links
- CD11a Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGAL Info with links in the Cell Migration Gateway
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