ITGAV

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.

Alpha V class integrins

In mammals the integrins that include alpha-V are :

Name	Synonyms	Distribution	Ligands
αVβ1		ocular melanoma; neurological tumors	vitronectin; fibrinogen
αVβ3	vitronectin receptor	activated endothelial cells, melanoma, glioblastoma	vitronectin, fibronectin, fibrinogen, osteopontin, Cyr61
αVβ5		widespread, esp. fibroblasts, epithelial cells	vitronectin and adenovirus
αVβ6		proliferating epithelia, esp. lung and mammary gland	fibronectin; TGFβ1+3
αVβ8		neural tissue; peripheral nerve	fibronectin; TGFβ1+3

As a drug target

The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.

See also

• Cluster of differentiation

Further reading

• University of Edinburgh. (2013, November 10). Hope for transplant patients as study finds key to organ scarring. ScienceDaily. Retrieved December 2, 2014 from www.sciencedaily.com/releases/2013/11/131110184408.htm

External links

• CD51 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGAV Info with links in the Cell Migration Gateway