Matrine

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Matrine
(+)-Matrine.svg
Systematic (IUPAC) name
(7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one
Clinical data
Legal status
  • Unscheduled
Identifiers
CAS Number 519-02-8 YesY
ATC code none
PubChem CID: 91466
ChemSpider 553788 YesY
ChEMBL CHEMBL204860 N
Chemical data
Formula C15H24N2O
Molecular mass 248.364 g/mol
  • C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1
  • InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m1/s1 YesY
  • Key:ZSBXGIUJOOQZMP-UKTARXLSSA-N YesY
 NYesY (what is this?)  (verify)

Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects,[1] and action as a kappa opioid receptor and µ-receptor agonist.[2][3]

Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities.[4] Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait.

Mu opioid agonism is associated with euphoria, while kappa opioid agonism is associated with dysphoria and psychotomimetic hallucinations (as seen in the kappa-agonist Salvinorin A). Both receptors are known to produce analgesia when activated.

Matrine and the related compound oxymatrine have an antifeedant effect against Formosan subterranean termite.[5]

References

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