Tynorphin
Lua error in package.lua at line 80: module 'strict' not found.
![]() |
|
Systematic (IUPAC) name | |
---|---|
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoic acid
|
|
Clinical data | |
Legal status |
|
Identifiers | |
ATC code | None |
PubChem | CID: 9961318 |
ChemSpider | 8136925 |
Chemical data | |
Formula | C35H46N6O7 |
Molecular mass | 662.8 g/mol |
|
|
|
Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides.[1] It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.[1] It has a pentapeptide structure with the amino acid sequence Val-Val-Tyr-Pro-Trp.
Tynorphin was discovered in an attempt to develop an enkephalinase inhibitor of greater potency than spinorphin.[1]
See also
References
<templatestyles src="Reflist/styles.css" />
Cite error: Invalid <references>
tag; parameter "group" is allowed only.
<references />
, or <references group="..." />
- Pages with reference errors
- Chemical articles having calculated molecular weight overwritten
- Chemical articles with unknown parameter in Infobox drug
- Infobox drug articles without a structure image
- Chemical articles without CAS Registry Number
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugs not assigned an ATC code
- Articles containing unverified chemical infoboxes
- Amines
- Indoles
- Opioids
- Peptides
- Propionic acids
- Pyrrolidines