SB-612,111

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SB-612,111
SB-612,111 structure.png
Systematic (IUPAC) name
(5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
Identifiers
CAS Number 371980-98-2 N
PubChem CID: 10047612
IUPHAR/BPS 1693
ChemSpider 8223175 N
ChEMBL CHEMBL559569 N
Synonyms SB-612,111
Chemical data
Formula C24H29Cl2NO
Molecular mass 418.398 g/mol
  • CC1=CC=CC2=C1CC[C@@H](C[C@@H]2O)CN3CCC(CC3)C4=C(C=CC=C4Cl)Cl
  • InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3/t17-,23-/m0/s1 N
  • Key:OHRDCQFCAWLDBP-SBUREZEXSA-N N
 NYesY (what is this?)  (verify)

SB-612,111 is an opioid receptor ligand which is a potent and selective antagonist for the nociceptin receptor (ORL-1), several times more potent than the older drug J-113,397.[1] It does not have analgesic effects in its own right, but prevents the development of hyperalgesia,[2] and also shows antidepressant effects in animal studies.[3]

See also

References

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  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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